Assay Detail
Binding
CHEMBL4628365
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Inhibition of latency-associated peptide/TGF-beta binding to recombinant human integrin alphaV (Phe31 to Val992 residues) beta6 (Gly22 to Asn707 residues) expressed in CHO cells by ELISA based solid phase binding assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel cilengitide-based cyclic RGD peptides as αvβ<sub>3</sub> integrin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.46 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2332369 | — | — | 1 | 7.48 |
| CHEMBL4648191 | — | — | 1 | 6.75 |
| CHEMBL4633117 | — | — | 1 | 6.42 |
| CHEMBL4642869 | — | — | 1 | 6.22 |
| CHEMBL4636873 | — | — | 1 | 6.15 |
| CHEMBL4643939 | — | — | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2332369 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4648191 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL4633117 | — | IC50 | = | 378.0 | nM | 6.42 |
| CHEMBL4642869 | — | IC50 | = | 608.0 | nM | 6.22 |
| CHEMBL4636873 | — | IC50 | = | 709.0 | nM | 6.15 |
| CHEMBL4643939 | — | IC50 | = | 1970.0 | nM | 5.71 |