Assay Detail
Binding
CHEMBL4628381
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Binding affinity to human D2 receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of C10 nitrogen-containing aporphines with dopamine D<sub>1</sub> versus D<sub>5</sub> receptor selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.43 | 8.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.71 |
| CHEMBL4637246 | — | — | 1 | 6.64 |
| CHEMBL4639398 | — | — | 1 | 6.58 |
| CHEMBL4636948 | — | — | 1 | 6.50 |
| CHEMBL4636589 | — | — | 1 | 6.37 |
| CHEMBL4646927 | — | — | 1 | 6.32 |
| CHEMBL4634039 | — | — | 1 | 6.17 |
| CHEMBL4649785 | — | — | 1 | 6.12 |
| CHEMBL4633772 | — | — | 1 | 6.07 |
| CHEMBL4636318 | — | — | 1 | 6.02 |
| CHEMBL4637673 | — | — | 1 | 6.01 |
| CHEMBL4638749 | — | — | 1 | 5.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 1.97 | nM | 8.71 |
| CHEMBL4637246 | — | Ki | = | 231.0 | nM | 6.64 |
| CHEMBL4639398 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL4636948 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL4636589 | — | Ki | = | 431.0 | nM | 6.37 |
| CHEMBL4646927 | — | Ki | = | 478.0 | nM | 6.32 |
| CHEMBL4634039 | — | Ki | = | 679.0 | nM | 6.17 |
| CHEMBL4649785 | — | Ki | = | 759.0 | nM | 6.12 |
| CHEMBL4633772 | — | Ki | = | 854.0 | nM | 6.07 |
| CHEMBL4636318 | — | Ki | = | 963.0 | nM | 6.02 |
| CHEMBL4637673 | — | Ki | = | 978.0 | nM | 6.01 |
| CHEMBL4638749 | — | Ki | = | 2048.0 | nM | 5.69 |