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Assay Detail

CHEMBL4628528

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of soybean 15-LOX using arachidonic acid or linoleic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 10 mins by colorimetric assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Glycine max
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes.
Maghraby MT, Abou-Ghadir OMF, Abdel-Moty SG, Ali AY, Salem OIA.
Bioorg Med Chem (2020) 28 : 115403 -115403
PubMed 32127262 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.49 5.78

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4647794 1 5.78
CHEMBL4636392 1 5.75
CHEMBL4642182 1 5.74
CHEMBL4639025 1 5.73
CHEMBL4642268 1 5.71
CHEMBL4636346 1 5.70
CHEMBL4643407 1 5.67
CHEMBL4648858 1 5.53
CHEMBL4644150 1 5.53
CHEMBL50 QUERCETIN 3.0 1 5.48
CHEMBL4637009 1 5.40
CHEMBL4640385 1 5.38
CHEMBL4633586 1 5.38
CHEMBL4637840 1 5.30
CHEMBL4649049 1 5.29
CHEMBL4634111 1 5.26
CHEMBL4633930 1 5.18
CHEMBL4639368 1 4.93

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4647794 IC50 = 1670.0 nM 5.78
CHEMBL4636392 IC50 = 1760.0 nM 5.75
CHEMBL4642182 IC50 = 1820.0 nM 5.74
CHEMBL4639025 IC50 = 1850.0 nM 5.73
CHEMBL4642268 IC50 = 1960.0 nM 5.71
CHEMBL4636346 IC50 = 1980.0 nM 5.70
CHEMBL4643407 IC50 = 2140.0 nM 5.67
CHEMBL4648858 IC50 = 2980.0 nM 5.53
CHEMBL4644150 IC50 = 2930.0 nM 5.53
CHEMBL50 QUERCETIN IC50 = 3340.0 nM 5.48
CHEMBL4637009 IC50 = 3980.0 nM 5.40
CHEMBL4640385 IC50 = 4150.0 nM 5.38
CHEMBL4633586 IC50 = 4120.0 nM 5.38
CHEMBL4637840 IC50 = 4960.0 nM 5.30
CHEMBL4649049 IC50 = 5110.0 nM 5.29
CHEMBL4634111 IC50 = 5460.0 nM 5.26
CHEMBL4633930 IC50 = 6560.0 nM 5.18
CHEMBL4639368 IC50 = 11870.0 nM 4.93