Assay Detail
Binding
CHEMBL4628530
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Inhibition of human recombinant COX2 using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 2 mins by EIA
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.87 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4647794 | — | — | 1 | 7.35 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 7.35 |
| CHEMBL4643407 | — | — | 1 | 7.27 |
| CHEMBL4639025 | — | — | 1 | 7.24 |
| CHEMBL4642268 | — | — | 1 | 7.17 |
| CHEMBL4639368 | — | — | 1 | 7.16 |
| CHEMBL4644150 | — | — | 1 | 7.16 |
| CHEMBL4648858 | — | — | 1 | 7.12 |
| CHEMBL4640385 | — | — | 1 | 6.85 |
| CHEMBL4637009 | — | — | 1 | 6.75 |
| CHEMBL4633586 | — | — | 1 | 6.72 |
| CHEMBL4649049 | — | — | 1 | 6.68 |
| CHEMBL4634111 | — | — | 1 | 6.66 |
| CHEMBL4633930 | — | — | 1 | 6.64 |
| CHEMBL4641800 | — | — | 1 | 6.60 |
| CHEMBL4637840 | — | — | 1 | 6.58 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 6.30 |
| CHEMBL1034 | DICLOFENAC SODIUM | 4.0 | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4647794 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL118 | CELECOXIB | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4643407 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4639025 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4642268 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL4639368 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4644150 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4648858 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL4640385 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4637009 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4633586 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4649049 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4634111 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4633930 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4641800 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4637840 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1034 | DICLOFENAC SODIUM | IC50 | = | 840.0 | nM | 6.08 |