Assay Detail
Binding
CHEMBL4628664
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IDH1 R132C mutant (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Isocitrate dehydrogenase [NADP] cytoplasmic (CHEMBL2007625) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of novel 2-arylbenzimidazoles as selective mutant isocitrate dehydrogenase 2 R140Q inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.41 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2180727 | — | — | 1 | 6.41 |
| CHEMBL3989908 | ENASIDENIB | 4.0 | 1 | - |
| CHEMBL3392845 | — | — | 1 | - |
| CHEMBL4643441 | — | — | 1 | - |
| CHEMBL4646777 | — | — | 1 | - |
| CHEMBL4634103 | — | — | 1 | - |
| CHEMBL4639434 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2180727 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL3989908 | ENASIDENIB | IC50 | > | 100000.0 | nM | - |
| CHEMBL3392845 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4643441 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4646777 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4634103 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4639434 | — | IC50 | > | 100000.0 | nM | - |