Assay Detail
Functional
CHEMBL4629072
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Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-MEL-28 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Drug repurposing and rediscovery: Design, synthesis and preliminary biological evaluation of 1-arylamino-3-aryloxypropan-2-ols as anti-melanoma agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 4.91 | 5.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4647987 | — | — | 1 | 5.48 |
| CHEMBL4632553 | — | — | 1 | 5.42 |
| CHEMBL4640999 | — | — | 1 | 5.42 |
| CHEMBL4649826 | — | — | 1 | 5.36 |
| CHEMBL4646099 | — | — | 1 | 5.30 |
| CHEMBL4647396 | — | — | 1 | 5.22 |
| CHEMBL4513932 | — | — | 1 | 5.18 |
| CHEMBL3799125 | — | — | 1 | 4.98 |
| CHEMBL4641718 | — | — | 1 | 4.94 |
| CHEMBL263149 | — | — | 1 | 4.92 |
| CHEMBL4161940 | — | — | 1 | 4.91 |
| CHEMBL2440825 | — | — | 1 | 4.87 |
| CHEMBL4648268 | — | — | 1 | 4.85 |
| CHEMBL2440845 | — | — | 1 | 4.85 |
| CHEMBL4643089 | — | — | 1 | 4.81 |
| CHEMBL723 | CARVEDILOL | 4.0 | 1 | 4.81 |
| CHEMBL4646676 | — | — | 1 | 4.81 |
| CHEMBL2440846 | — | — | 1 | 4.73 |
| CHEMBL4637718 | — | — | 1 | 4.72 |
| CHEMBL4633203 | — | — | 1 | 4.71 |
| CHEMBL4640312 | — | — | 1 | 4.70 |
| CHEMBL4638494 | — | — | 1 | 4.61 |
| CHEMBL4641529 | — | — | 1 | 4.60 |
| CHEMBL324665 | CARAZOLOL | 2.0 | 1 | 4.50 |
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | 4.12 |
| CHEMBL429 | LABETALOL | 4.0 | 1 | - |
| CHEMBL13 | METOPROLOL | 4.0 | 1 | - |
| CHEMBL768 | ESMOLOL | 4.0 | 1 | - |
| CHEMBL499 | TIMOLOL | 4.0 | 1 | - |
| CHEMBL645 | BISOPROLOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4647987 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4632553 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4640999 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4649826 | — | IC50 | = | 4390.0 | nM | 5.36 |
| CHEMBL4646099 | — | IC50 | = | 4990.0 | nM | 5.30 |
| CHEMBL4647396 | — | IC50 | = | 6010.0 | nM | 5.22 |
| CHEMBL4513932 | — | IC50 | = | 6660.0 | nM | 5.18 |
| CHEMBL3799125 | — | IC50 | = | 10520.0 | nM | 4.98 |
| CHEMBL4641718 | — | IC50 | = | 11440.0 | nM | 4.94 |
| CHEMBL263149 | — | IC50 | = | 11880.0 | nM | 4.92 |
| CHEMBL4161940 | — | IC50 | = | 12450.0 | nM | 4.91 |
| CHEMBL2440825 | — | IC50 | = | 13450.0 | nM | 4.87 |
| CHEMBL4648268 | — | IC50 | = | 14250.0 | nM | 4.85 |
| CHEMBL2440845 | — | IC50 | = | 14070.0 | nM | 4.85 |
| CHEMBL723 | CARVEDILOL | IC50 | = | 15550.0 | nM | 4.81 |
| CHEMBL4646676 | — | IC50 | = | 15540.0 | nM | 4.81 |
| CHEMBL4643089 | — | IC50 | = | 15330.0 | nM | 4.81 |
| CHEMBL2440846 | — | IC50 | = | 18530.0 | nM | 4.73 |
| CHEMBL4637718 | — | IC50 | = | 19150.0 | nM | 4.72 |
| CHEMBL4633203 | — | IC50 | = | 19710.0 | nM | 4.71 |
| CHEMBL4640312 | — | IC50 | = | 19840.0 | nM | 4.70 |
| CHEMBL4638494 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL4641529 | — | IC50 | = | 25010.0 | nM | 4.60 |
| CHEMBL324665 | CARAZOLOL | IC50 | = | 31280.0 | nM | 4.50 |
| CHEMBL27 | PROPRANOLOL | IC50 | = | 75820.0 | nM | 4.12 |
| CHEMBL429 | LABETALOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL13 | METOPROLOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL768 | ESMOLOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL499 | TIMOLOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL645 | BISOPROLOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL471 | SOTALOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL24 | ATENOLOL | IC50 | > | 100000.0 | nM | - |