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Assay Detail

CHEMBL4629190

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 7 (CHEMBL3155)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Chemical puzzles in the search for new, flexible derivatives of lurasidone as antipsychotic drugs.
Zaręba P, Drabczyk AK, Jaśkowska J, Satała G.
Bioorg Med Chem (2020) 28 : 115459 -115459
PubMed 32247749 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 23 7.19 8.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4643450 1 8.15
CHEMBL4638308 1 8.15
CHEMBL4641609 1 8.05
CHEMBL4642981 1 7.80
CHEMBL4636031 1 7.52
CHEMBL4645525 1 7.51
CHEMBL4637294 1 7.44
CHEMBL4641296 1 7.43
CHEMBL4635363 1 7.41
CHEMBL4636435 1 7.28
CHEMBL4638388 1 7.27
CHEMBL4635603 1 7.14
CHEMBL4645793 1 7.00
CHEMBL4642594 1 6.98
CHEMBL38409 1 6.94
CHEMBL4646868 1 6.93
CHEMBL4639203 1 6.93
CHEMBL4645292 1 6.84
CHEMBL4648390 1 6.71
CHEMBL4645308 1 6.70
CHEMBL4632519 1 6.70
CHEMBL4644906 1 6.41
CHEMBL4648581 1 6.13

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4643450 Ki = 7.0 nM 8.15
CHEMBL4638308 Ki = 7.0 nM 8.15
CHEMBL4641609 Ki = 9.0 nM 8.05
CHEMBL4642981 Ki = 16.0 nM 7.80
CHEMBL4636031 Ki = 30.0 nM 7.52
CHEMBL4645525 Ki = 31.0 nM 7.51
CHEMBL4637294 Ki = 36.0 nM 7.44
CHEMBL4641296 Ki = 37.0 nM 7.43
CHEMBL4635363 Ki = 39.0 nM 7.41
CHEMBL4636435 Ki = 53.0 nM 7.28
CHEMBL4638388 Ki = 54.0 nM 7.27
CHEMBL4635603 Ki = 72.0 nM 7.14
CHEMBL4645793 Ki = 99.0 nM 7.00
CHEMBL4642594 Ki = 105.0 nM 6.98
CHEMBL38409 Ki = 114.0 nM 6.94
CHEMBL4646868 Ki = 118.0 nM 6.93
CHEMBL4639203 Ki = 117.0 nM 6.93
CHEMBL4645292 Ki = 146.0 nM 6.84
CHEMBL4648390 Ki = 193.0 nM 6.71
CHEMBL4645308 Ki = 198.0 nM 6.70
CHEMBL4632519 Ki = 202.0 nM 6.70
CHEMBL4644906 Ki = 387.0 nM 6.41
CHEMBL4648581 Ki = 747.0 nM 6.13