Assay Detail
Functional
CHEMBL4629253
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Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.53 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2048720 | — | — | 1 | 9.22 |
| CHEMBL4642515 | — | — | 1 | 9.10 |
| CHEMBL4637048 | — | — | 1 | 8.85 |
| CHEMBL4634835 | — | — | 1 | 8.68 |
| CHEMBL4643083 | — | — | 1 | 8.66 |
| CHEMBL4640640 | — | — | 1 | 8.48 |
| CHEMBL4636627 | — | — | 1 | 8.43 |
| CHEMBL4641292 | — | — | 1 | 8.29 |
| CHEMBL1096380 | PLINABULIN | 3.0 | 1 | 8.18 |
| CHEMBL4646725 | — | — | 1 | 8.15 |
| CHEMBL3342339 | — | — | 1 | 8.15 |
| CHEMBL4640318 | — | — | 1 | 8.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2048720 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4642515 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4637048 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4634835 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4643083 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4640640 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4636627 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4641292 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL1096380 | PLINABULIN | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL4646725 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3342339 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4640318 | — | IC50 | = | 7.4 | nM | 8.13 |