Assay Detail

CHEMBL4629485

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Functional

Effect on mitoxantrone-induced cytotoxicity against human S1 cells by measuring mitoxantrone IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 4.83 +/- 0.83 nM)

ChEMBL ↗

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Target

S1 (CHEMBL4630779) ↗

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Primary target S1

CHEMBL4630779

Anchored from Assay target.

Protein identity S1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	S1
Confidence	1 — Organism
Curated By	Autocuration

Target

S1 (CHEMBL4630779) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Licochalcone A Selectively Resensitizes ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Chemotherapeutic Drugs.

Wu CP, Lusvarghi S, Hsiao SH, Liu TC, Li YQ, Huang YH, Hung TH, Ambudkar SV.
J Nat Prod (2020) 83 : 1461 -1472
PubMed 32347726 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.34	8.34

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL139702	LICOAGROCHACONE A	—	1	8.34

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL139702	LICOAGROCHACONE A	IC50	=	4.55	nM	8.34