Assay Detail
Binding
CHEMBL4629622
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at THRbeta (unknown origin) incubated for 14 to 16 hrs by dual glo luciferase reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
l-Thyroxin and the Nonclassical Thyroid Hormone TETRAC Are Potent Activators of PPARγ.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.12 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4637025 | — | — | 1 | 7.72 |
| CHEMBL549748 | TETRAC | -1.0 | 1 | 7.70 |
| CHEMBL1624 | LEVOTHYROXINE | 4.0 | 1 | 6.62 |
| CHEMBL4638870 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4637025 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL549748 | TETRAC | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1624 | LEVOTHYROXINE | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4638870 | — | EC50 | = | 380.0 | nM | 6.42 |