Assay Detail
ADMET
CHEMBL4630009
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Cytotoxicity against human NHLF cells incubated for 3 days by [3H]thymidine incorporation based scintillation counting method
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.65 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4639538 | — | — | 1 | 5.96 |
| CHEMBL4634866 | — | — | 1 | 5.89 |
| CHEMBL4639676 | — | — | 1 | 5.85 |
| CHEMBL4637363 | — | — | 1 | 5.82 |
| CHEMBL4635108 | — | — | 1 | 5.75 |
| CHEMBL4639774 | — | — | 1 | 5.70 |
| CHEMBL4640920 | — | — | 1 | 5.66 |
| CHEMBL4641927 | — | — | 1 | 5.52 |
| CHEMBL3693618 | — | — | 1 | 5.47 |
| CHEMBL3693624 | — | — | 1 | 5.41 |
| CHEMBL3693620 | — | — | 1 | 5.41 |
| CHEMBL4649366 | — | — | 1 | 5.34 |
| CHEMBL4638326 | — | — | 1 | - |
| CHEMBL4635687 | — | — | 1 | - |
| CHEMBL4632796 | — | — | 1 | - |
| CHEMBL4649779 | — | — | 1 | - |
| CHEMBL3969009 | — | — | 1 | - |
| CHEMBL4638316 | — | — | 1 | - |
| CHEMBL4642854 | — | — | 1 | - |
| CHEMBL4643358 | — | — | 1 | - |
| CHEMBL4645444 | — | — | 1 | - |
| CHEMBL3693628 | — | — | 1 | - |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | - |
| CHEMBL4639731 | — | — | 1 | - |
| CHEMBL3689519 | — | — | 1 | - |
| CHEMBL4639875 | — | — | 1 | - |
| CHEMBL3693599 | — | — | 1 | - |
| CHEMBL3693625 | — | — | 1 | - |
| CHEMBL3693592 | — | — | 1 | - |
| CHEMBL3693596 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4639538 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4634866 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4639676 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4637363 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4635108 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4639774 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4640920 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4641927 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3693618 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL3693620 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3693624 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4649366 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4644221 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4636510 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL4646256 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL4637879 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4632611 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4638326 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4635687 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4632796 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4649779 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3969009 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4638316 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4642854 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4643358 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4645444 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3693628 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL221959 | TOFACITINIB | IC50 | > | 10000.0 | nM | - |
| CHEMBL4639731 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3689519 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4639875 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3693599 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3693625 | — | IC50 | - | — | - | |
| CHEMBL3693592 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3693596 | — | IC50 | - | — | - |