Assay Detail
Binding
CHEMBL4630545
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Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta42 levels incubated for 5 hrs by sandwich immuno-assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Generation of Leads for γ-Secretase Modulation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.92 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4632652 | — | — | 1 | 7.82 |
| CHEMBL1950434 | — | — | 1 | 7.54 |
| CHEMBL2180376 | — | — | 1 | 7.48 |
| CHEMBL1950535 | — | — | 1 | 7.43 |
| CHEMBL2312555 | — | — | 1 | 7.41 |
| CHEMBL4641625 | — | — | 1 | 7.32 |
| CHEMBL4643105 | — | — | 1 | 7.28 |
| CHEMBL4634921 | — | — | 1 | 7.26 |
| CHEMBL1224151 | — | — | 1 | 7.19 |
| CHEMBL4648298 | — | — | 1 | 7.16 |
| CHEMBL4634696 | — | — | 1 | 6.97 |
| CHEMBL4637679 | — | — | 1 | 6.95 |
| CHEMBL1643425 | — | — | 1 | 6.94 |
| CHEMBL4642697 | — | — | 1 | 6.84 |
| CHEMBL4636430 | — | — | 1 | 6.40 |
| CHEMBL4639757 | — | — | 1 | 6.33 |
| CHEMBL4643160 | — | — | 1 | 6.29 |
| CHEMBL4639056 | — | — | 1 | 5.81 |
| CHEMBL4644009 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4632652 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1950434 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2180376 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1950535 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL2312555 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4641625 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4643105 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4634921 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1224151 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4648298 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4634696 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL4637679 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL1643425 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL4642697 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL4636430 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4639757 | — | IC50 | = | 462.0 | nM | 6.33 |
| CHEMBL4643160 | — | IC50 | = | 512.0 | nM | 6.29 |
| CHEMBL4639056 | — | IC50 | = | 1554.0 | nM | 5.81 |
| CHEMBL4644009 | — | IC50 | = | 9289.0 | nM | 5.03 |