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Assay Detail

CHEMBL4649963

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Functional
To identify inhibition of the IFN signalling (Jak-Stat) pathway via expression of an eGFP reporter gene under the control of an IFN-stimulated response element (ISRE) containing MxA promoter.
ChEMBL ↗
8998
Total Activities
8841
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

University of Dundee, Small-Polar-MMV Screening Library
University of Dundee
(2021)
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Percent Effect 8841 - -
IC50 157 5.00 6.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3469542 — — 4 6.46
CHEMBL3469582 — — 5 5.93
CHEMBL3444101 — — 5 5.93
CHEMBL3444098 — — 5 5.87
CHEMBL3469650 — — 5 5.81
CHEMBL3469978 — — 5 5.79
CHEMBL3470148 — — 5 5.79
CHEMBL3495249 — — 2 5.71
CHEMBL3450556 — — 5 5.60
CHEMBL3496425 — — 3 5.60
CHEMBL3495567 — — 3 5.55
CHEMBL3495489 — — 3 5.55
CHEMBL3444564 — — 3 5.46
CHEMBL3496434 — — 3 5.45
CHEMBL3469778 — — 3 5.27
CHEMBL3496480 — — 3 5.24
CHEMBL3500941 — — 3 5.20
CHEMBL3498315 — — 3 5.14
CHEMBL3494600 — — 3 5.14
CHEMBL3494616 — — 3 5.12
CHEMBL3495575 — — 3 5.12
CHEMBL3496127 — — 3 5.11
CHEMBL3495569 — — 3 5.10
CHEMBL3503541 — — 3 5.10
CHEMBL3494230 — — 2 5.09
CHEMBL3495490 — — 3 5.07
CHEMBL3444322 — — 3 5.00
CHEMBL3472179 — — 3 4.95
CHEMBL3494750 — — 3 4.93
CHEMBL3493922 — — 3 4.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3469542 — IC50 = 346.74 nM 6.46
CHEMBL3469582 — IC50 = 1164.33 nM 5.93
CHEMBL3444101 — IC50 = 1165.44 nM 5.93
CHEMBL3444098 — IC50 = 1341.29 nM 5.87
CHEMBL3444101 — IC50 = 1404.64 nM 5.85
CHEMBL3469650 — IC50 = 1536.32 nM 5.81
CHEMBL3469650 — IC50 = 1610.71 nM 5.79
CHEMBL3470148 — IC50 = 1612.38 nM 5.79
CHEMBL3469978 — IC50 = 1619.35 nM 5.79
CHEMBL3469978 — IC50 = 1636.13 nM 5.79
CHEMBL3469582 — IC50 = 1736.71 nM 5.76
CHEMBL3470148 — IC50 = 1722.18 nM 5.76
CHEMBL3444098 — IC50 = 1880.73 nM 5.73
CHEMBL3495249 — IC50 = 1929.65 nM 5.71
CHEMBL3469582 — IC50 = 2207.61 nM 5.66
CHEMBL3470148 — IC50 = 2336.71 nM 5.63
CHEMBL3444098 — IC50 = 2399.38 nM 5.62
CHEMBL3450556 — IC50 = 2527.82 nM 5.60
CHEMBL3450556 — IC50 = 2504.38 nM 5.60
CHEMBL3496425 — IC50 = 2532.09 nM 5.60
CHEMBL3450556 — IC50 = 2558.99 nM 5.59
CHEMBL3444098 — IC50 = 2776.88 nM 5.56
CHEMBL3469582 — IC50 = 2837.48 nM 5.55
CHEMBL3495567 — IC50 = 2826.32 nM 5.55
CHEMBL3495489 — IC50 = 2812.61 nM 5.55
CHEMBL3444101 — IC50 = 2870.2 nM 5.54
CHEMBL3469650 — IC50 = 3091.73 nM 5.51
CHEMBL3469978 — IC50 = 3266.77 nM 5.49
CHEMBL3450556 — IC50 = 3384.81 nM 5.47
CHEMBL3444564 — IC50 = 3428.52 nM 5.46
CHEMBL3496434 — IC50 = 3555.68 nM 5.45
CHEMBL3444101 — IC50 = 4355.54 nM 5.36
CHEMBL3470148 — IC50 = 4756.98 nM 5.32
CHEMBL3469978 — IC50 = 5024.86 nM 5.30
CHEMBL3444564 — IC50 = 5166.79 nM 5.29
CHEMBL3469778 — IC50 = 5397.04 nM 5.27
CHEMBL3496480 — IC50 = 5721.15 nM 5.24
CHEMBL3495567 — IC50 = 5724.06 nM 5.24
CHEMBL3500941 — IC50 = 6256.23 nM 5.20
CHEMBL3496425 — IC50 = 6317.53 nM 5.20
CHEMBL3496480 — IC50 = 6648.12 nM 5.18
CHEMBL3494600 — IC50 = 7299.28 nM 5.14
CHEMBL3498315 — IC50 = 7213.13 nM 5.14
CHEMBL3469778 — IC50 = 7275.01 nM 5.14
CHEMBL3494616 — IC50 = 7587.0 nM 5.12
CHEMBL3495575 — IC50 = 7567.68 nM 5.12
CHEMBL3496127 — IC50 = 7808.27 nM 5.11
CHEMBL3495569 — IC50 = 7868.99 nM 5.10
CHEMBL3503541 — IC50 = 7963.86 nM 5.10
CHEMBL3494230 — IC50 = 8086.88 nM 5.09