Assay Detail
Binding
CHEMBL4650206
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Reverse ITC (compound as receptor). Domain start/stop: L1451-E1580
2
Total Activities
2
Compounds Tested
1
Activity Types
3
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Category | ITC assay |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
EUbOPEN bromodomain assay panel
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 5.88 | 7.05 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Protein Sequence | Protein Sequence | - | — | MHHHHHHSSGVDLGTENLYFQSMLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEE |
| Refseq Start/Stop | Refseq Start/Stop | - | — | L1451-E1580 |
| Target UniProt Accession | Target UniProt Accession | - | — | P51532 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3752911 | — | — | 1 | 7.05 |
| CHEMBL3133807 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3752911 | — | Kd | = | 89.0 | nM | 7.05 |
| CHEMBL3133807 | — | Kd | = | 19685.0 | nM | 4.71 |