Assay Detail
Binding
CHEMBL4666141
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant mouse CLK1 expressed in bacteria using GRSRSRSRSRSR as substrate in presence of [gamma-33P]ATP
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein kinase CLK1 (CHEMBL1075280) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.95 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4778413 | — | — | 1 | 7.75 |
| CHEMBL4784564 | — | — | 1 | 7.21 |
| CHEMBL4763099 | — | — | 1 | 6.93 |
| CHEMBL4791275 | — | — | 1 | 6.92 |
| CHEMBL4759771 | — | — | 1 | 6.92 |
| CHEMBL4780720 | — | — | 1 | 6.90 |
| CHEMBL4785650 | — | — | 1 | 6.88 |
| CHEMBL4794934 | — | — | 1 | 6.80 |
| CHEMBL4755373 | — | — | 1 | 6.68 |
| CHEMBL4748345 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4778413 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4784564 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4763099 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL4791275 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4759771 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4780720 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL4785650 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL4794934 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4755373 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4748345 | — | IC50 | = | 290.0 | nM | 6.54 |