Assay Detail
Functional
CHEMBL4666228
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.74 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2035835 | CLAULANSINE F | — | 1 | 5.58 |
| CHEMBL4785995 | — | — | 1 | 5.42 |
| CHEMBL4756640 | — | — | 1 | 5.36 |
| CHEMBL4752610 | — | — | 1 | 5.08 |
| CHEMBL4747612 | — | — | 1 | 5.01 |
| CHEMBL786 | TAMOXIFEN CITRATE | 4.0 | 1 | 4.89 |
| CHEMBL4780732 | — | — | 1 | 4.71 |
| CHEMBL4747972 | — | — | 1 | 4.63 |
| CHEMBL4756222 | — | — | 1 | 4.55 |
| CHEMBL4749329 | — | — | 1 | 4.54 |
| CHEMBL4777848 | — | — | 1 | 4.51 |
| CHEMBL4764555 | — | — | 1 | 4.48 |
| CHEMBL4746389 | — | — | 1 | 4.44 |
| CHEMBL4788145 | — | — | 1 | 4.43 |
| CHEMBL4760705 | — | — | 1 | 4.33 |
| CHEMBL4742668 | — | — | 1 | 4.33 |
| CHEMBL4785117 | — | — | 1 | 4.28 |
| CHEMBL4758896 | — | — | 1 | - |
| CHEMBL4781975 | — | — | 1 | - |
| CHEMBL4795902 | — | — | 1 | - |
| CHEMBL4762745 | — | — | 1 | - |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2035835 | CLAULANSINE F | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4785995 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4756640 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4752610 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4747612 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL786 | TAMOXIFEN CITRATE | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL4780732 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL4747972 | — | IC50 | = | 23200.0 | nM | 4.63 |
| CHEMBL4756222 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4749329 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL4777848 | — | IC50 | = | 30700.0 | nM | 4.51 |
| CHEMBL4764555 | — | IC50 | = | 33400.0 | nM | 4.48 |
| CHEMBL4746389 | — | IC50 | = | 36500.0 | nM | 4.44 |
| CHEMBL4788145 | — | IC50 | = | 36700.0 | nM | 4.43 |
| CHEMBL4760705 | — | IC50 | = | 46500.0 | nM | 4.33 |
| CHEMBL4742668 | — | IC50 | = | 46500.0 | nM | 4.33 |
| CHEMBL4785117 | — | IC50 | = | 52400.0 | nM | 4.28 |
| CHEMBL4758896 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4781975 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4795902 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4762745 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL53463 | DOXORUBICIN | IC50 | - | — | - |