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Assay Detail

CHEMBL4666358

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant PGAM1 by measuring decrease in OD by enzyme based assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Phosphoglycerate mutase 1 (CHEMBL3334418)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and biological evaluation of anthraquinone derivatives as allosteric phosphoglycerate mutase 1 inhibitors for cancer treatment.
Huang K,Jiang L,Liang R,Li H,Ruan X,Shan C,Ye D,Zhou L
Eur J Med Chem (2019) 168 : 45 -57
PubMed 30798052 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 6.13 7.01

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4760337 1 7.01
CHEMBL4763924 1 6.85
CHEMBL4789955 1 6.72
CHEMBL4741748 1 6.60
CHEMBL4784572 1 6.58
CHEMBL4742013 1 6.48
CHEMBL4757633 1 6.44
CHEMBL4759807 1 6.32
CHEMBL4752163 1 6.31
CHEMBL4798515 1 6.26
CHEMBL4743623 1 6.26
CHEMBL4762201 1 6.20
CHEMBL4787732 1 6.08
CHEMBL4752963 1 5.89
CHEMBL4745620 1 5.82
CHEMBL4747578 1 5.76
CHEMBL4790666 1 5.69
CHEMBL4746342 1 5.69
CHEMBL4793513 1 5.58
CHEMBL4756511 1 5.55
CHEMBL4782282 1 5.54
CHEMBL4747649 1 5.27
CHEMBL4756114 1 -
CHEMBL4749276 1 -
CHEMBL4749380 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4760337 IC50 = 97.0 nM 7.01
CHEMBL4763924 IC50 = 140.0 nM 6.85
CHEMBL4789955 IC50 = 190.0 nM 6.72
CHEMBL4741748 IC50 = 250.0 nM 6.60
CHEMBL4784572 IC50 = 260.0 nM 6.58
CHEMBL4742013 IC50 = 330.0 nM 6.48
CHEMBL4757633 IC50 = 360.0 nM 6.44
CHEMBL4759807 IC50 = 480.0 nM 6.32
CHEMBL4752163 IC50 = 490.0 nM 6.31
CHEMBL4798515 IC50 = 550.0 nM 6.26
CHEMBL4743623 IC50 = 550.0 nM 6.26
CHEMBL4762201 IC50 = 630.0 nM 6.20
CHEMBL4787732 IC50 = 840.0 nM 6.08
CHEMBL4752963 IC50 = 1290.0 nM 5.89
CHEMBL4745620 IC50 = 1500.0 nM 5.82
CHEMBL4747578 IC50 = 1750.0 nM 5.76
CHEMBL4790666 IC50 = 2050.0 nM 5.69
CHEMBL4746342 IC50 = 2050.0 nM 5.69
CHEMBL4793513 IC50 = 2600.0 nM 5.58
CHEMBL4756511 IC50 = 2810.0 nM 5.55
CHEMBL4782282 IC50 = 2860.0 nM 5.54
CHEMBL4747649 IC50 = 5370.0 nM 5.27
CHEMBL4756114 IC50 > 10000.0 nM -
CHEMBL4749276 IC50 > 10000.0 nM -
CHEMBL4749380 IC50 > 10000.0 nM -