Assay Detail
Functional
CHEMBL4666360
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Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of anthraquinone derivatives as allosteric phosphoglycerate mutase 1 inhibitors for cancer treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.89 | 5.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4742013 | — | — | 1 | 5.20 |
| CHEMBL4763924 | — | — | 1 | 5.17 |
| CHEMBL4752163 | — | — | 1 | 5.09 |
| CHEMBL4793513 | — | — | 1 | 5.04 |
| CHEMBL4741748 | — | — | 1 | 4.99 |
| CHEMBL4760337 | — | — | 1 | 4.95 |
| CHEMBL4784572 | — | — | 1 | 4.92 |
| CHEMBL4743623 | — | — | 1 | 4.91 |
| CHEMBL4798515 | — | — | 1 | 4.67 |
| CHEMBL4757633 | — | — | 1 | 4.59 |
| CHEMBL4752963 | — | — | 1 | 4.30 |
| CHEMBL4789955 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4742013 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4763924 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4752163 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL4793513 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL4741748 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4760337 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL4784572 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4743623 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL4798515 | — | IC50 | = | 21600.0 | nM | 4.67 |
| CHEMBL4757633 | — | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL4752963 | — | IC50 | = | 50500.0 | nM | 4.30 |
| CHEMBL4789955 | — | IC50 | > | 100000.0 | nM | - |