Assay Detail
Binding
CHEMBL4667323
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of human TREK2 by thallium flux mobilization assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Potassium channel subfamily K member 10 (CHEMBL2331041) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Towards a TREK-1/2 (TWIK-Related K+ Channel 1 and 2) dual activator tool compound: Multi-dimensional optimization of BL-1249.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 5.07 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4745050 | — | — | 1 | 5.30 |
| CHEMBL4759521 | — | — | 1 | 5.26 |
| CHEMBL4795261 | — | — | 1 | 5.25 |
| CHEMBL4747631 | — | — | 1 | 5.23 |
| CHEMBL4776102 | — | — | 1 | 5.17 |
| CHEMBL4780579 | — | — | 1 | 5.12 |
| CHEMBL1417584 | — | — | 1 | 5.11 |
| CHEMBL4759642 | — | — | 1 | 5.11 |
| CHEMBL4784090 | — | — | 1 | 4.58 |
| CHEMBL4758530 | — | — | 1 | 4.54 |
| CHEMBL4778307 | — | — | 1 | - |
| CHEMBL4747514 | — | — | 1 | - |
| CHEMBL4788471 | — | — | 1 | - |
| CHEMBL4746675 | — | — | 1 | - |
| CHEMBL4741520 | — | — | 1 | - |
| CHEMBL4749533 | — | — | 1 | - |
| CHEMBL4744719 | — | — | 1 | - |
| CHEMBL4750436 | — | — | 1 | - |
| CHEMBL4750599 | — | — | 1 | - |
| CHEMBL4761929 | — | — | 1 | - |
| CHEMBL4741659 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4745050 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4759521 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4795261 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4747631 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4776102 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4780579 | — | EC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL1417584 | — | EC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4759642 | — | EC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4784090 | — | EC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL4758530 | — | EC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL4778307 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL4747514 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL4788471 | — | EC50 | - | — | - | |
| CHEMBL4746675 | — | EC50 | - | — | - | |
| CHEMBL4741520 | — | EC50 | - | — | - | |
| CHEMBL4749533 | — | EC50 | - | — | - | |
| CHEMBL4744719 | — | EC50 | - | — | - | |
| CHEMBL4750436 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL4750599 | — | EC50 | < | 3600.0 | nM | - |
| CHEMBL4761929 | — | EC50 | - | — | - | |
| CHEMBL4741659 | — | EC50 | > | 30000.0 | nM | - |