Assay Detail
Binding
CHEMBL4667656
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to PPARalpha (unknown origin) by TR-FRET assay
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2-Phenyl-8-(1-phenylallyl)-chromenone compounds have a pan-PPAR modulator pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.49 | 8.92 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL21241 | GW7647 | — | 1 | 8.92 |
| CHEMBL4746218 | — | — | 1 | 6.02 |
| CHEMBL4746258 | — | — | 1 | 5.62 |
| CHEMBL295416 | PIRINIXIC ACID | 2.0 | 1 | 5.38 |
| CHEMBL595 | PIOGLITAZONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL21241 | GW7647 | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL4746218 | — | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL4746258 | — | Ki | = | 2410.0 | nM | 5.62 |
| CHEMBL295416 | PIRINIXIC ACID | Ki | = | 4130.0 | nM | 5.38 |
| CHEMBL595 | PIOGLITAZONE | Activity | - | — | - |