Assay Detail
Binding
CHEMBL4667908
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SPP in human U2OS cells cotransfected with EGFP-labeled EnvSigSeq-SEAP incubated for 24 hrs by Hoechst staining based Cellomics ArrayScan analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Orally Active Hydroxyethylamine Based SPPL2a Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.50 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4759048 | — | — | 1 | 6.19 |
| CHEMBL4753654 | — | — | 1 | 5.82 |
| CHEMBL4740837 | — | — | 1 | 5.75 |
| CHEMBL4762492 | — | — | 1 | 5.70 |
| CHEMBL4789381 | — | — | 1 | 5.50 |
| CHEMBL4759943 | — | — | 1 | 5.48 |
| CHEMBL4792187 | — | — | 1 | 5.41 |
| CHEMBL4762370 | — | — | 1 | 5.09 |
| CHEMBL4741014 | — | — | 1 | 4.58 |
| CHEMBL4798232 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4759048 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4753654 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4740837 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4762492 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4789381 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4759943 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4792187 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4762370 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL4741014 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL4798232 | — | IC50 | > | 32000.0 | nM | - |