Assay Detail
Functional
CHEMBL4668385
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Antiproliferative activity against human LoVo/DX cells incubated for 72 hrs by sulforhodamine B assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Lovo/DX |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Colchicine Alkaloids and Synthetic Analogues: Current Progress and Perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.56 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4778455 | — | — | 1 | 8.70 |
| CHEMBL4754716 | — | — | 1 | 8.70 |
| CHEMBL4747315 | — | — | 1 | 8.30 |
| CHEMBL4784821 | — | — | 1 | 8.15 |
| CHEMBL4788263 | — | — | 1 | 8.15 |
| CHEMBL4743337 | — | — | 1 | 8.10 |
| CHEMBL4741117 | — | — | 1 | 8.10 |
| CHEMBL4749049 | — | — | 1 | 8.00 |
| CHEMBL4781237 | — | — | 1 | 7.96 |
| CHEMBL4787421 | — | — | 1 | 7.70 |
| CHEMBL4746666 | — | — | 1 | 7.70 |
| CHEMBL4795688 | — | — | 1 | 7.57 |
| CHEMBL4743514 | — | — | 1 | 7.40 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.27 |
| CHEMBL4760534 | — | — | 1 | 7.11 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.04 |
| CHEMBL4755367 | — | — | 1 | 7.03 |
| CHEMBL4791804 | — | — | 1 | 7.01 |
| CHEMBL4743081 | — | — | 1 | 6.96 |
| CHEMBL4458551 | — | — | 1 | 6.87 |
| CHEMBL4780304 | — | — | 1 | 6.40 |
| CHEMBL4779080 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4778455 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4754716 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4747315 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4784821 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4788263 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4743337 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4741117 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4749049 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4781237 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4787421 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4746666 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4795688 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4743514 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL107 | COLCHICINE | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4760534 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4755367 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL4791804 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL4743081 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL4458551 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL4780304 | — | IC50 | = | 398.0 | nM | 6.40 |
| CHEMBL4779080 | — | IC50 | = | 642.0 | nM | 6.19 |