Assay Detail
ADMET
CHEMBL4668430
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Cytotoxicity against human HeLa cells after 24 to 72 hrs by Cell Titer Blue assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Colchicine Alkaloids and Synthetic Analogues: Current Progress and Perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.33 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL357889 | — | — | 1 | 8.15 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.24 |
| CHEMBL4783480 | — | — | 1 | 6.66 |
| CHEMBL4750970 | — | — | 1 | 6.64 |
| CHEMBL4748240 | — | — | 1 | 5.92 |
| CHEMBL4753602 | — | — | 1 | 5.91 |
| CHEMBL4746569 | — | — | 1 | 5.83 |
| CHEMBL4786044 | — | — | 1 | 5.33 |
| CHEMBL4753996 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL357889 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL107 | COLCHICINE | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4783480 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4750970 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4748240 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL4753602 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL4746569 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL4786044 | — | IC50 | = | 4620.0 | nM | 5.33 |
| CHEMBL4753996 | — | IC50 | = | 4930.0 | nM | 5.31 |