Assay Detail
Binding
CHEMBL4668476
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Allosteric inhibition of dPEG8 peptide-activated SHP2 (unknown origin) using DiFMUP as substrate preincubated for 30 followed by substrate addition and measured after 30 mins by fluorescence method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 11 (CHEMBL3864) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent Advances of SHP2 Inhibitors in Cancer Therapy: Current Development and Clinical Application.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.25 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4752599 | — | — | 1 | 8.52 |
| CHEMBL4789817 | — | — | 1 | 8.40 |
| CHEMBL4752704 | — | — | 1 | 8.15 |
| CHEMBL4761760 | — | — | 1 | 8.10 |
| CHEMBL4792498 | — | — | 1 | 8.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4752599 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4789817 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4752704 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4761760 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4792498 | — | IC50 | = | 8.3 | nM | 8.08 |