Assay Detail
ADMET
CHEMBL4668533
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal His-tagged human AKR1B10 expressed in Escherichia coli BL21 (Condon Plus) competent cells using pyridine-3-aldehydenone as substrate in presence of NADPH by fluorescence method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B10 (CHEMBL5983) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Overview of AKR1C3: Inhibitor Achievements and Disease Insights.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.41 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | — | 1 | 6.41 |
| CHEMBL277346 | OCTYL_GALLATE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL277346 | OCTYL_GALLATE | IC50 | > | 100000.0 | nM | - |