Assay Detail

CHEMBL4668587

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Binding

Inhibition of human ROCK2 expressed in baculovirus expression system by Kinase-Glo luminescent Assay

ChEMBL ↗

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Target

Rho-associated protein kinase 2 (CHEMBL2973) ↗

Open DB target context

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Rho-associated protein kinase 2 (CHEMBL2973) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Rho-associated protein kinase 2

CHEMBL2973

Anchored from Assay target.

Protein identity Rho-associated protein kinase 2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Rho-associated protein kinase 2 (CHEMBL2973) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Ocular Disease Therapeutics: Design and Delivery of Drugs for Diseases of the Eye.

Cheng KJ,Hsieh CM,Nepali K,Liou JP
J Med Chem (2020) 63 : 10533 -10593
PubMed 32482069 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	9.70	9.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4753043	NETARSUDIL-M1	-1.0	1	9.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4753043	NETARSUDIL-M1	Ki	=	0.2	nM	9.70