Assay Detail
Binding
CHEMBL4668629
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of C-terminal His6-tagged human CypD K133I mutant expressed in Escherichia coli BL21(DE3) using Suc-Ala-Ala-Cis-Pro-Phe-pNA as substrate by spectrophotometric analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Fragment Linking Strategies for Structure-Based Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.96 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4092230 | — | — | 1 | 6.70 |
| CHEMBL3647424 | — | — | 1 | 5.21 |
| CHEMBL3408644 | — | — | 1 | - |
| CHEMBL4745604 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4092230 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3647424 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3408644 | — | IC50 | > | 5000000.0 | nM | - |
| CHEMBL4745604 | — | IC50 | > | 5000000.0 | nM | - |