Assay Detail
Binding
CHEMBL4668690
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Inhibition of CD73 in human PBMC using AMP as substrate preincubated for 60 mins followed by substrate addition and measured after 2.5 hrs by PiColorLock gold reagent based colorimetric assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of AB680: A Potent and Selective Inhibitor of CD73.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 10.82 | 10.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4471306 | QUEMLICLUSTAT | 2.0 | 1 | 10.96 |
| CHEMBL4761506 | — | — | 1 | 10.68 |
| CHEMBL4743437 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4471306 | QUEMLICLUSTAT | IC50 | = | 0.011 | nM | 10.96 |
| CHEMBL4761506 | — | IC50 | = | 0.021 | nM | 10.68 |
| CHEMBL4743437 | — | IC50 | = | 0.0085 | nM | - |