Assay Detail
Functional
CHEMBL4668803
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Cytotoxicity against human Hs-578T cells assessed as reduction in cell viability after 48 hrs by SRB assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Hs-578T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Triple-Negative Breast Cancer Cells Exhibit Differential Sensitivity to Cardenolides from Calotropis gigantea.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.41 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL500585 | USCHARIN | — | 1 | 7.47 |
| CHEMBL495949 | CALOTROPIN | — | 1 | 7.22 |
| CHEMBL1751 | DIGOXIN | 4.0 | 1 | 7.16 |
| CHEMBL4743046 | — | — | 1 | 6.92 |
| CHEMBL4797949 | — | — | 1 | 6.52 |
| CHEMBL4781168 | — | — | 1 | 6.42 |
| CHEMBL449767 | DESGLUCOUZARIN | — | 1 | 5.80 |
| CHEMBL495179 | COROGLAUCIGENIN | — | 1 | 5.75 |
| CHEMBL109863 | — | — | 1 | 5.44 |
| CHEMBL4776690 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL500585 | USCHARIN | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL495949 | CALOTROPIN | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1751 | DIGOXIN | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4743046 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4797949 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4781168 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL449767 | DESGLUCOUZARIN | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL495179 | COROGLAUCIGENIN | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL109863 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4776690 | — | IC50 | = | 3900.0 | nM | 5.41 |