Assay Detail

CHEMBL4668986

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of human neutrophil elastase

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Neutrophil elastase (CHEMBL248) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Neutrophil elastase (CHEMBL248) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Neutrophil elastase

CHEMBL248

Anchored from Assay target.

Protein identity Neutrophil elastase

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Neutrophil elastase (CHEMBL248) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Lung Protection by Cathepsin C Inhibition: A New Hope for COVID-19 and ARDS?

Korkmaz B,Lesner A,Marchand-Adam S,Moss C,Jenne DE
J Med Chem (2020) 63 : 13258 -13265
PubMed 32692176 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.36	7.36
Ki	1	6.70	6.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL76688	SIVELESTAT	3.0	2	7.36

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL76688	SIVELESTAT	IC50	=	44.0	nM	7.36
CHEMBL76688	SIVELESTAT	Ki	=	200.0	nM	6.70