Assay Detail
Functional
CHEMBL4669539
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Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of ring-fused pyrazoloamino pyridine/pyrimidine derivatives as potential FAK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.32 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3040440 | VS-4718 | 1.0 | 1 | 7.54 |
| CHEMBL4800129 | — | — | 1 | 6.85 |
| CHEMBL4748255 | — | — | 1 | 6.60 |
| CHEMBL4776318 | — | — | 1 | 6.48 |
| CHEMBL4792928 | — | — | 1 | 6.35 |
| CHEMBL4786602 | — | — | 1 | 6.23 |
| CHEMBL4781502 | — | — | 1 | 6.13 |
| CHEMBL4742859 | — | — | 1 | 6.13 |
| CHEMBL4761718 | — | — | 1 | 5.50 |
| CHEMBL4742157 | GSK-2256098 | 2.0 | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3040440 | VS-4718 | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4800129 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4748255 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4776318 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4792928 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4786602 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL4781502 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4742859 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4761718 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4742157 | GSK-2256098 | IC50 | = | 3820.0 | nM | 5.42 |