Assay Detail
Binding
CHEMBL4669544
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Binding affinity to CM5 chip immobilized beta tubulin (unknown origin) assessed as thermodynamic constants by SPR assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Discovery of noscapine derivatives as potential β-tubulin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 6.92 | 7.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4797381 | — | — | 1 | 7.67 |
| CHEMBL4756812 | — | — | 1 | 7.43 |
| CHEMBL4751205 | — | — | 1 | 6.88 |
| CHEMBL4797299 | — | — | 1 | 6.88 |
| CHEMBL4747307 | — | — | 1 | 6.43 |
| CHEMBL364713 | NOSCAPINE | 2.0 | 1 | 6.24 |
| CHEMBL4792014 | — | — | 1 | - |
| CHEMBL4754682 | — | — | 1 | - |
| CHEMBL4778340 | — | — | 1 | - |
| CHEMBL4764952 | — | — | 1 | - |
| CHEMBL4758024 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4797381 | — | Kd | = | 21.5 | nM | 7.67 |
| CHEMBL4756812 | — | Kd | = | 36.9 | nM | 7.43 |
| CHEMBL4751205 | — | Kd | = | 133.0 | nM | 6.88 |
| CHEMBL4797299 | — | Kd | = | 132.0 | nM | 6.88 |
| CHEMBL4747307 | — | Kd | = | 374.3 | nM | 6.43 |
| CHEMBL364713 | NOSCAPINE | Kd | = | 579.0 | nM | 6.24 |
| CHEMBL4792014 | — | Kd | - | — | - | |
| CHEMBL4754682 | — | Kd | - | — | - | |
| CHEMBL4778340 | — | Kd | - | — | - | |
| CHEMBL4764952 | — | Kd | - | — | - | |
| CHEMBL4758024 | — | Kd | - | — | - |