Assay Detail
Binding
CHEMBL4669779
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FITC-HIF1alpha (556 to 574 residues) binding to PHD2 (181 to 426 residues) (unknown origin) by fluorescence polarization assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Clinical Candidate (5-(3-(4-Chlorophenoxy)prop-1-yn-1-yl)-3-hydroxypicolinoyl)glycine, an Orally Bioavailable Prolyl Hydroxylase Inhibitor for the Treatment of Anemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.40 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4162752 | DDO-3055 | 1.0 | 1 | 7.19 |
| CHEMBL4795349 | — | — | 1 | 7.15 |
| CHEMBL4776330 | — | — | 1 | 7.07 |
| CHEMBL4754277 | — | — | 1 | 6.96 |
| CHEMBL4756482 | — | — | 1 | 6.90 |
| CHEMBL4755522 | — | — | 1 | 6.77 |
| CHEMBL4760023 | — | — | 1 | 6.76 |
| CHEMBL4747660 | — | — | 1 | 6.73 |
| CHEMBL4763404 | — | — | 1 | 6.73 |
| CHEMBL4760527 | — | — | 1 | 6.66 |
| CHEMBL4760608 | — | — | 1 | 6.59 |
| CHEMBL4746856 | — | — | 1 | 6.58 |
| CHEMBL4756775 | — | — | 1 | 6.49 |
| CHEMBL4789825 | — | — | 1 | 6.46 |
| CHEMBL4749938 | — | — | 1 | 6.42 |
| CHEMBL4742972 | — | — | 1 | 6.39 |
| CHEMBL4753537 | — | — | 1 | 6.37 |
| CHEMBL4748127 | — | — | 1 | 6.35 |
| CHEMBL4763948 | — | — | 1 | 6.35 |
| CHEMBL4757255 | — | — | 1 | 6.34 |
| CHEMBL4781270 | — | — | 1 | 6.29 |
| CHEMBL4779610 | — | — | 1 | 6.28 |
| CHEMBL4788975 | — | — | 1 | 6.23 |
| CHEMBL2338329 | ROXADUSTAT | 4.0 | 1 | 6.23 |
| CHEMBL4745628 | — | — | 1 | 6.19 |
| CHEMBL4746310 | — | — | 1 | 6.09 |
| CHEMBL4796091 | — | — | 1 | 6.08 |
| CHEMBL4745866 | — | — | 1 | 6.08 |
| CHEMBL4781276 | — | — | 1 | 6.06 |
| CHEMBL4743029 | — | — | 1 | 5.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4162752 | DDO-3055 | IC50 | = | 64.2 | nM | 7.19 |
| CHEMBL4795349 | — | IC50 | = | 70.4 | nM | 7.15 |
| CHEMBL4776330 | — | IC50 | = | 84.3 | nM | 7.07 |
| CHEMBL4754277 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4756482 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL4755522 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL4760023 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL4747660 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL4763404 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL4760527 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL4760608 | — | IC50 | = | 256.0 | nM | 6.59 |
| CHEMBL4746856 | — | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL4756775 | — | IC50 | = | 326.0 | nM | 6.49 |
| CHEMBL4789825 | — | IC50 | = | 346.0 | nM | 6.46 |
| CHEMBL4749938 | — | IC50 | = | 378.0 | nM | 6.42 |
| CHEMBL4742972 | — | IC50 | = | 408.0 | nM | 6.39 |
| CHEMBL4753537 | — | IC50 | = | 428.0 | nM | 6.37 |
| CHEMBL4748127 | — | IC50 | = | 444.0 | nM | 6.35 |
| CHEMBL4763948 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4757255 | — | IC50 | = | 454.0 | nM | 6.34 |
| CHEMBL4781270 | — | IC50 | = | 514.0 | nM | 6.29 |
| CHEMBL4779610 | — | IC50 | = | 527.0 | nM | 6.28 |
| CHEMBL4788975 | — | IC50 | = | 587.0 | nM | 6.23 |
| CHEMBL2338329 | ROXADUSTAT | IC50 | = | 591.0 | nM | 6.23 |
| CHEMBL4745628 | — | IC50 | = | 651.0 | nM | 6.19 |
| CHEMBL4746310 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4796091 | — | IC50 | = | 825.0 | nM | 6.08 |
| CHEMBL4745866 | — | IC50 | = | 835.0 | nM | 6.08 |
| CHEMBL4781276 | — | IC50 | = | 877.0 | nM | 6.06 |
| CHEMBL4743029 | — | IC50 | = | 1073.0 | nM | 5.97 |
| CHEMBL4789028 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4127286 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4759967 | — | IC50 | = | 8103.0 | nM | 5.09 |