Assay Detail

CHEMBL4669878

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Inhibition of DNL in po dosed Sprague-Dawley rat assessed as reduction in DNL level in liver pretreated with one hr followed by [14C]-acetate treatment and measured after 1 hr

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Rattus norvegicus
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting.

Huard K,Smith AC,Cappon G,Dow RL,Edmonds DJ,El-Kattan A,Esler WP,Fernando DP,Griffith DA,Kalgutkar AS,Ross TT,Bagley SW,Beebe D,Bi YA,Cabral S,Crowley C,Doran SD,Dowling MS,Liras S,Mascitti V,Niosi M,Pfefferkorn JA,Polivkova J,Préville C,Price DA,Shavnya A,Shirai N,Smith AH,Southers JR,Tess DA,Thuma BA,Varma MV,Yang X
J Med Chem (2020) 63 : 10879 -10896
PubMed 32809824 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Inhibition	1	-	-
EC50	1	8.27	8.27

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4567446	CLESACOSTAT	2.0	2	8.27

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4567446	CLESACOSTAT	EC50	=	5.4	nM	8.27
CHEMBL4567446	CLESACOSTAT	Inhibition		-	%	-