Assay Detail

CHEMBL4669922

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Binding

Uncompetitive inhibition of human ACC2 incubated for 15 mins in presence of ATP by Line weaver-Burk plot analysis

ChEMBL ↗

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Target

Acetyl-CoA carboxylase 2 (CHEMBL4829) ↗

Open DB target context

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Acetyl-CoA carboxylase 2 (CHEMBL4829) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Acetyl-CoA carboxylase 2

CHEMBL4829

Anchored from Assay target.

Protein identity Acetyl-CoA carboxylase 2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Acetyl-CoA carboxylase 2 (CHEMBL4829) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting.

Huard K,Smith AC,Cappon G,Dow RL,Edmonds DJ,El-Kattan A,Esler WP,Fernando DP,Griffith DA,Kalgutkar AS,Ross TT,Bagley SW,Beebe D,Bi YA,Cabral S,Crowley C,Doran SD,Dowling MS,Liras S,Mascitti V,Niosi M,Pfefferkorn JA,Polivkova J,Préville C,Price DA,Shavnya A,Shirai N,Smith AH,Southers JR,Tess DA,Thuma BA,Varma MV,Yang X
J Med Chem (2020) 63 : 10879 -10896
PubMed 32809824 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.06	8.06

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4567446	CLESACOSTAT	2.0	1	8.06

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4567446	CLESACOSTAT	IC50	=	8.66	nM	8.06