Assay Detail
Functional
CHEMBL4669987
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Antiproliferative activity against Con A-induced BALB/c mouse T cell after 48 hrs by CCK8 assay
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | T cell line |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and Biological Evaluation of Celastrol Derivatives as Potential Immunosuppressive Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 6.36 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3417314 | — | — | 1 | 7.60 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 7.58 |
| CHEMBL3928971 | — | — | 1 | 7.51 |
| CHEMBL3417318 | — | — | 1 | 7.20 |
| CHEMBL3980631 | — | — | 1 | 7.19 |
| CHEMBL301982 | CELASTROL | — | 1 | 7.08 |
| CHEMBL3951763 | — | — | 1 | 7.08 |
| CHEMBL4756214 | — | — | 1 | 6.95 |
| CHEMBL4781489 | — | — | 1 | 6.69 |
| CHEMBL3952862 | — | — | 1 | 6.65 |
| CHEMBL4761350 | — | — | 1 | 6.53 |
| CHEMBL4760191 | — | — | 1 | 6.51 |
| CHEMBL3943005 | — | — | 1 | 6.49 |
| CHEMBL4752565 | — | — | 1 | 6.44 |
| CHEMBL4751648 | — | — | 1 | 6.34 |
| CHEMBL4791763 | — | — | 1 | 6.14 |
| CHEMBL4076720 | — | — | 1 | 6.13 |
| CHEMBL4762467 | — | — | 1 | 6.11 |
| CHEMBL3417313 | — | — | 1 | 6.09 |
| CHEMBL1172284 | — | — | 1 | 6.03 |
| CHEMBL4752202 | — | — | 1 | 6.00 |
| CHEMBL1170915 | — | — | 1 | 5.98 |
| CHEMBL4763181 | — | — | 1 | 5.98 |
| CHEMBL4764335 | — | — | 1 | 5.97 |
| CHEMBL4749841 | — | — | 1 | 5.96 |
| CHEMBL4782984 | — | — | 1 | 5.95 |
| CHEMBL4088297 | — | — | 1 | 5.93 |
| CHEMBL54804 | PRISTIMERIN | — | 1 | 5.92 |
| CHEMBL4789502 | — | — | 1 | 5.90 |
| CHEMBL4739965 | — | — | 1 | 5.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3417314 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3928971 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3417318 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3980631 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL301982 | CELASTROL | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL3951763 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL4756214 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL4781489 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL3952862 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL4761350 | — | IC50 | = | 294.0 | nM | 6.53 |
| CHEMBL4760191 | — | IC50 | = | 312.0 | nM | 6.51 |
| CHEMBL3943005 | — | IC50 | = | 323.0 | nM | 6.49 |
| CHEMBL4752565 | — | IC50 | = | 362.0 | nM | 6.44 |
| CHEMBL4751648 | — | IC50 | = | 454.0 | nM | 6.34 |
| CHEMBL4791763 | — | IC50 | = | 721.0 | nM | 6.14 |
| CHEMBL4076720 | — | IC50 | = | 739.0 | nM | 6.13 |
| CHEMBL4762467 | — | IC50 | = | 771.0 | nM | 6.11 |
| CHEMBL3417313 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL1172284 | — | IC50 | = | 924.0 | nM | 6.03 |
| CHEMBL4752202 | — | IC50 | = | 994.0 | nM | 6.00 |
| CHEMBL4763181 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL1170915 | — | IC50 | = | 1055.0 | nM | 5.98 |
| CHEMBL4764335 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL4749841 | — | IC50 | = | 1088.0 | nM | 5.96 |
| CHEMBL4782984 | — | IC50 | = | 1121.0 | nM | 5.95 |
| CHEMBL4088297 | — | IC50 | = | 1181.0 | nM | 5.93 |
| CHEMBL54804 | PRISTIMERIN | IC50 | = | 1202.0 | nM | 5.92 |
| CHEMBL4789502 | — | IC50 | = | 1255.0 | nM | 5.90 |
| CHEMBL4739965 | — | IC50 | = | 1462.0 | nM | 5.83 |
| CHEMBL4795000 | — | IC50 | = | 1548.0 | nM | 5.81 |
| CHEMBL4758598 | — | IC50 | = | 1602.0 | nM | 5.79 |
| CHEMBL4754442 | — | IC50 | = | 1875.0 | nM | 5.73 |
| CHEMBL4747134 | — | IC50 | = | 4872.0 | nM | 5.31 |
| CHEMBL4799068 | — | IC50 | >= | 10000.0 | nM | - |
| CHEMBL4777722 | — | IC50 | >= | 10000.0 | nM | - |
| CHEMBL4751024 | — | IC50 | >= | 10000.0 | nM | - |
| CHEMBL4757421 | — | IC50 | >= | 10000.0 | nM | - |
| CHEMBL4751479 | — | IC50 | >= | 10000.0 | nM | - |
| CHEMBL4748195 | — | IC50 | >= | 10000.0 | nM | - |
| CHEMBL4762383 | — | IC50 | >= | 10000.0 | nM | - |
| CHEMBL4752220 | — | IC50 | >= | 10000.0 | nM | - |
| CHEMBL4747229 | — | IC50 | >= | 10000.0 | nM | - |
| CHEMBL4754179 | — | IC50 | >= | 10000.0 | nM | - |