Assay Detail
Functional
CHEMBL4670019
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Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in o-positive erythrocyte assessed as reduction in parasite growth
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | Erythrocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial activity of tetrahydro-β-carbolines targeting the ATP binding pocket of the Plasmodium falciparum heat shock 90 protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 5.32 | 6.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4756130 | — | — | 1 | 6.45 |
| CHEMBL4778230 | — | — | 1 | 5.78 |
| CHEMBL4790446 | — | — | 1 | 5.71 |
| CHEMBL4795781 | — | — | 1 | 5.68 |
| CHEMBL4748527 | — | — | 1 | 5.60 |
| CHEMBL4752798 | — | — | 1 | 5.36 |
| CHEMBL4742882 | — | — | 1 | 5.35 |
| CHEMBL4755025 | — | — | 1 | 5.15 |
| CHEMBL4795286 | — | — | 1 | 5.12 |
| CHEMBL4783435 | — | — | 1 | 4.96 |
| CHEMBL4764937 | — | — | 1 | 4.92 |
| CHEMBL4743505 | — | — | 1 | 4.88 |
| CHEMBL4757837 | — | — | 1 | 4.78 |
| CHEMBL4749189 | — | — | 1 | 4.75 |
| CHEMBL4778647 | — | — | 1 | - |
| CHEMBL4795665 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4756130 | — | EC50 | = | 352.0 | nM | 6.45 |
| CHEMBL4778230 | — | EC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL4790446 | — | EC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL4795781 | — | EC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL4748527 | — | EC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL4752798 | — | EC50 | = | 4350.0 | nM | 5.36 |
| CHEMBL4742882 | — | EC50 | = | 4450.0 | nM | 5.35 |
| CHEMBL4755025 | — | EC50 | = | 7060.0 | nM | 5.15 |
| CHEMBL4795286 | — | EC50 | = | 7530.0 | nM | 5.12 |
| CHEMBL4783435 | — | EC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL4764937 | — | EC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL4743505 | — | EC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL4757837 | — | EC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL4749189 | — | EC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL4778647 | — | EC50 | > | 18000.0 | nM | - |
| CHEMBL4795665 | — | EC50 | > | 18000.0 | nM | - |