Assay Detail
Binding
CHEMBL4670130
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Antagonist activity at 5HT2C receptor (unknown origin) by radioligand binding assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure activity relationship exploration of 5-hydroxy-2-(3-phenylpropyl)chromones as a unique 5-HT receptor antagonist scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.70 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4795598 | — | — | 1 | 6.10 |
| CHEMBL4755344 | — | — | 1 | 5.70 |
| CHEMBL4763861 | — | — | 1 | 5.50 |
| CHEMBL4741776 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4795598 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL4755344 | — | Ki | = | 1995.26 | nM | 5.70 |
| CHEMBL4763861 | — | Ki | = | 3162.28 | nM | 5.50 |
| CHEMBL4741776 | — | Ki | = | 3162.28 | nM | 5.50 |