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Assay Detail

CHEMBL4670184

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Functional
Antiproliferative activities against human U-251 cells by SRB assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type U-251
Confidence 1 — Organism
Curated By Autocuration

Target

U-251 (CHEMBL615022)
Type CELL-LINE
Organism Homo sapiens

Publication

Bioactive Alkaloids from the Actinomycete Actinoalloteichus sp. ZZ1866.
Qin L,Yi W,Lian XY,Zhang Z
J Nat Prod (2020) 83 : 2686 -2695
PubMed 32864967 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 4.90 5.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4791630 1 5.70
CHEMBL53463 DOXORUBICIN 4.0 1 5.41
CHEMBL4763301 1 5.24
CHEMBL4754075 1 4.92
CHEMBL4757657 1 4.92
CHEMBL1928402 1 4.92
CHEMBL4789230 1 4.89
CHEMBL4784386 1 4.82
CHEMBL4761582 1 4.77
CHEMBL4756703 1 4.72
CHEMBL4740296 1 4.57
CHEMBL4748065 1 4.44
CHEMBL4758385 1 4.44

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4791630 IC50 = 2000.0 nM 5.70
CHEMBL53463 DOXORUBICIN IC50 = 3900.0 nM 5.41
CHEMBL4763301 IC50 = 5800.0 nM 5.24
CHEMBL4754075 IC50 = 12000.0 nM 4.92
CHEMBL4757657 IC50 = 12000.0 nM 4.92
CHEMBL1928402 IC50 = 12000.0 nM 4.92
CHEMBL4789230 IC50 = 13000.0 nM 4.89
CHEMBL4784386 IC50 = 15000.0 nM 4.82
CHEMBL4761582 IC50 = 17000.0 nM 4.77
CHEMBL4756703 IC50 = 19000.0 nM 4.72
CHEMBL4740296 IC50 = 27000.0 nM 4.57
CHEMBL4748065 IC50 = 36000.0 nM 4.44
CHEMBL4758385 IC50 = 36000.0 nM 4.44