Assay Detail
Binding
CHEMBL4670192
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant N-terminal His-tagged full-length human PI3K p120gamma expressed in Sf9 insect cells using phosphatidylinositol 4,5-bisphosphate as substrate preincubated for 60 mins followed by substrate addition and measured after 1 hr in presence of ATP by ADP-Glo lipid kinase assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Potent and Selective PI3Kγ Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 7.78 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4740423 | — | — | 1 | 9.00 |
| CHEMBL4778393 | — | — | 1 | 8.89 |
| CHEMBL4782083 | — | — | 1 | 8.72 |
| CHEMBL4742062 | — | — | 1 | 8.68 |
| CHEMBL4743121 | — | — | 1 | 8.68 |
| CHEMBL4785086 | — | — | 1 | 8.66 |
| CHEMBL4762555 | — | — | 1 | 8.66 |
| CHEMBL4759380 | — | — | 1 | 8.57 |
| CHEMBL4755842 | — | — | 1 | 8.54 |
| CHEMBL4789901 | — | — | 1 | 8.54 |
| CHEMBL4126445 | — | — | 1 | 8.44 |
| CHEMBL4784554 | — | — | 1 | 8.36 |
| CHEMBL4764627 | — | — | 1 | 8.26 |
| CHEMBL4779748 | — | — | 1 | 8.23 |
| CHEMBL4798877 | — | — | 1 | 8.19 |
| CHEMBL4740304 | — | — | 1 | 8.18 |
| CHEMBL4792935 | — | — | 1 | 8.14 |
| CHEMBL4783357 | — | — | 1 | 8.12 |
| CHEMBL4761503 | — | — | 1 | 8.10 |
| CHEMBL4740608 | — | — | 1 | 8.04 |
| CHEMBL4755285 | — | — | 1 | 7.85 |
| CHEMBL4752240 | — | — | 1 | 7.82 |
| CHEMBL4782224 | — | — | 1 | 7.77 |
| CHEMBL4740456 | — | — | 1 | 7.51 |
| CHEMBL4745355 | — | — | 1 | 7.36 |
| CHEMBL4752359 | — | — | 1 | 7.30 |
| CHEMBL4749404 | — | — | 1 | 7.28 |
| CHEMBL4797944 | — | — | 1 | 7.22 |
| CHEMBL4752498 | — | — | 1 | 7.19 |
| CHEMBL4742806 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4740423 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4778393 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4782083 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4742062 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4743121 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4785086 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4762555 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4759380 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4755842 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4789901 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4126445 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL4784554 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL4764627 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL4779748 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL4798877 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL4740304 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL4792935 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL4783357 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL4761503 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4740608 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL4755285 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4752240 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4782224 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4740456 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4745355 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4752359 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4749404 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4797944 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4752498 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4742806 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4791781 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL4793165 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4744486 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL4746682 | — | IC50 | = | 291.0 | nM | 6.54 |
| CHEMBL4743136 | — | IC50 | = | 429.0 | nM | 6.37 |
| CHEMBL4764239 | — | IC50 | = | 425.0 | nM | 6.37 |
| CHEMBL4746190 | — | IC50 | = | 482.0 | nM | 6.32 |
| CHEMBL4794833 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4762674 | — | IC50 | > | 10000.0 | nM | - |