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Assay Detail

CHEMBL4670472

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Clostridium botulinum BoNT/A using SNAP-25 (141-206) as substrate by HPLC analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Clostridium botulinum
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Botulinum neurotoxin type A (CHEMBL5192)
Type SINGLE PROTEIN
Organism Clostridium botulinum

Publication

Catch and Anchor Approach To Combat Both Toxicity and Longevity of Botulinum Toxin A.
Lin L,Olson ME,Sugane T,Turner LD,Tararina MA,Nielsen AL,Kurbanov EK,Pellett S,Johnson EA,Cohen SM,Allen KN,Janda KD
J Med Chem (2020) 63 : 11100 -11120
PubMed 32886509 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 6.52 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL237370 CINNAMIC ACID HYDROXAMATE 1 6.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL237370 CINNAMIC ACID HYDROXAMATE Ki = 300.0 nM 6.52