Assay Detail
Functional
CHEMBL4670542
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Antiviral activity against pseudotyped Ebola virus - Mayinga, Zaire infected in human A549 cells assessed as reduction in viral infection incubated for 48 hrs by luciferase reporter gene assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Zaire ebolavirus |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.60 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4751531 | — | — | 1 | 8.22 |
| CHEMBL4754810 | — | — | 1 | 8.00 |
| CHEMBL4761341 | — | — | 1 | 8.00 |
| CHEMBL392916 | — | — | 1 | 7.70 |
| CHEMBL4782391 | — | — | 1 | 7.70 |
| CHEMBL4757636 | — | — | 1 | 7.52 |
| CHEMBL1655 | TOREMIFENE | 4.0 | 1 | 7.16 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 7.00 |
| CHEMBL28211 | NAFOXIDINE | 2.0 | 1 | 7.00 |
| CHEMBL4745844 | — | — | 1 | 6.89 |
| CHEMBL226329 | — | — | 1 | 6.89 |
| CHEMBL4796723 | — | — | 1 | 6.75 |
| CHEMBL4795040 | — | — | 1 | 6.64 |
| CHEMBL4297509 | ELACESTRANT | 4.0 | 1 | 6.62 |
| CHEMBL4741938 | — | — | 1 | 6.58 |
| CHEMBL226327 | — | — | 1 | 6.52 |
| CHEMBL4743737 | — | — | 1 | 6.48 |
| CHEMBL4742939 | — | — | 1 | 6.46 |
| CHEMBL4746824 | — | — | 1 | 6.20 |
| CHEMBL4760524 | — | — | 1 | 6.13 |
| CHEMBL4797649 | — | — | 1 | 6.10 |
| CHEMBL226269 | — | — | 1 | 6.01 |
| CHEMBL4532671 | — | — | 1 | 5.99 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 5.91 |
| CHEMBL520107 | — | — | 1 | 5.88 |
| CHEMBL4543096 | — | — | 1 | 5.88 |
| CHEMBL4747864 | — | — | 1 | 5.82 |
| CHEMBL4754864 | — | — | 1 | 5.76 |
| CHEMBL4751659 | — | — | 1 | 5.67 |
| CHEMBL46740 | BAZEDOXIFENE | 4.0 | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4751531 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4754810 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4761341 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL392916 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4782391 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4757636 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1655 | TOREMIFENE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL28211 | NAFOXIDINE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4745844 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL226329 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4796723 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4795040 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4297509 | ELACESTRANT | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4741938 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL226327 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4743737 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4742939 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4746824 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4760524 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4797649 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL226269 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL4532671 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL81 | RALOXIFENE | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL520107 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL4543096 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL4747864 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4754864 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL4751659 | — | IC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL46740 | BAZEDOXIFENE | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL2105395 | OSPEMIFENE | IC50 | = | 3800.0 | nM | 5.42 |