Assay Detail
Binding
CHEMBL4670705
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human LDHA using sodium pyruvate as substrate preincubated for 5 mins followed by diaphorase/resazurin addition and measured after 20 mins by fluorescence based assay
89
Total Activities
89
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 89 | 7.32 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4792513 | — | — | 1 | 9.00 |
| CHEMBL4786682 | — | — | 1 | 8.52 |
| CHEMBL4797357 | — | — | 1 | 8.30 |
| CHEMBL4752940 | — | — | 1 | 8.22 |
| CHEMBL4749903 | — | — | 1 | 8.15 |
| CHEMBL4759378 | — | — | 1 | 8.15 |
| CHEMBL4747300 | — | — | 1 | 8.15 |
| CHEMBL4783945 | — | — | 1 | 8.10 |
| CHEMBL4790159 | — | — | 1 | 8.10 |
| CHEMBL4759499 | — | — | 1 | 8.10 |
| CHEMBL4786717 | — | — | 1 | 8.05 |
| CHEMBL4760911 | — | — | 1 | 8.05 |
| CHEMBL4783252 | — | — | 1 | 8.05 |
| CHEMBL4794789 | — | — | 1 | 8.05 |
| CHEMBL4777867 | — | — | 1 | 8.05 |
| CHEMBL4751495 | — | — | 1 | 8.00 |
| CHEMBL4787940 | — | — | 1 | 7.96 |
| CHEMBL4752751 | — | — | 1 | 7.96 |
| CHEMBL4740977 | — | — | 1 | 7.92 |
| CHEMBL4783367 | — | — | 1 | 7.89 |
| CHEMBL4763489 | — | — | 1 | 7.85 |
| CHEMBL4762989 | — | — | 1 | 7.85 |
| CHEMBL4754755 | — | — | 1 | 7.82 |
| CHEMBL4758290 | — | — | 1 | 7.82 |
| CHEMBL4746658 | — | — | 1 | 7.82 |
| CHEMBL4751355 | — | — | 1 | 7.82 |
| CHEMBL4784731 | — | — | 1 | 7.80 |
| CHEMBL4784520 | — | — | 1 | 7.77 |
| CHEMBL4761628 | — | — | 1 | 7.68 |
| CHEMBL4782843 | — | — | 1 | 7.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4792513 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4786682 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4797357 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4752940 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4749903 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4759378 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4747300 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4783945 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4790159 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4759499 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4783252 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4777867 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4794789 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4760911 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4786717 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4751495 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4787940 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4752751 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4740977 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4783367 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4763489 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4762989 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4751355 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4746658 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4754755 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4758290 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4784731 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4784520 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4761628 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4782843 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4786033 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4741188 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4786241 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4785391 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4081890 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4788048 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4752866 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4746456 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4758227 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4742726 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4791940 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4762895 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4756608 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4777976 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4755095 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4761804 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4754861 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4786346 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4753379 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4763797 | — | IC50 | = | 43.0 | nM | 7.37 |