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Assay Detail

CHEMBL4670709

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Functional
Cytotoxicity against human MIA PaCa-2 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay
ChEMBL ↗
89
Total Activities
89
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MIA PaCa-2
Confidence 1 — Organism
Curated By Autocuration

Target

MIA PaCa-2 (CHEMBL614725) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties.
Rai G,Urban DJ,Mott BT,Hu X,Yang SM,Benavides GA,Johnson MS,Squadrito GL,Brimacombe KR,Lee TD,Cheff DM,Zhu H,Henderson MJ,Pohida K,Sulikowski GA,Dranow DM,Kabir M,Shah P,Padilha E,Tao D,Fang Y,Christov PP,Kim K,Jana S,Muttil P,Anderson T,Kunda NK,Hathaway HJ,Kusewitt DF,Oshima N,Cherukuri M,Davies DR,Norenberg JP,Sklar LA,Moore WJ,Dang CV,Stott GM,Neckers L,Flint AJ,Darley-Usmar VM,Simeonov A,Waterson AG,Jadhav A,Hall MD,Maloney DJ
J Med Chem (2020) 63 : 10984 -11011
PubMed 32902275 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 89 6.01 6.86

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4793796 — — 1 6.86
CHEMBL4758255 — — 1 6.77
CHEMBL4762895 — — 1 6.76
CHEMBL4788048 — — 1 6.66
CHEMBL4785391 — — 1 6.66
CHEMBL4747737 — — 1 6.65
CHEMBL4744588 — — 1 6.65
CHEMBL4748782 — — 1 6.59
CHEMBL4799344 — — 1 6.58
CHEMBL4791940 — — 1 6.57
CHEMBL4754861 — — 1 6.53
CHEMBL4782843 — — 1 6.50
CHEMBL4787940 — — 1 6.49
CHEMBL4777867 — — 1 6.49
CHEMBL4780015 — — 1 6.48
CHEMBL4756159 — — 1 6.47
CHEMBL4753379 — — 1 6.46
CHEMBL4784520 — — 1 6.44
CHEMBL4751209 — — 1 6.42
CHEMBL4759404 — — 1 6.40
CHEMBL4779276 — — 1 6.34
CHEMBL4764953 — — 1 6.34
CHEMBL4758312 — — 1 6.33
CHEMBL4783367 — — 1 6.33
CHEMBL4294999 — — 1 6.33
CHEMBL4756608 — — 1 6.31
CHEMBL4745150 — — 1 6.30
CHEMBL4752751 — — 1 6.28
CHEMBL4747960 — — 1 6.28
CHEMBL4751956 — — 1 6.27

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4793796 — IC50 = 137.0 nM 6.86
CHEMBL4758255 — IC50 = 171.0 nM 6.77
CHEMBL4762895 — IC50 = 173.0 nM 6.76
CHEMBL4788048 — IC50 = 219.0 nM 6.66
CHEMBL4785391 — IC50 = 218.0 nM 6.66
CHEMBL4747737 — IC50 = 226.0 nM 6.65
CHEMBL4744588 — IC50 = 223.0 nM 6.65
CHEMBL4748782 — IC50 = 257.0 nM 6.59
CHEMBL4799344 — IC50 = 265.0 nM 6.58
CHEMBL4791940 — IC50 = 268.0 nM 6.57
CHEMBL4754861 — IC50 = 296.0 nM 6.53
CHEMBL4782843 — IC50 = 314.0 nM 6.50
CHEMBL4787940 — IC50 = 322.0 nM 6.49
CHEMBL4777867 — IC50 = 323.0 nM 6.49
CHEMBL4780015 — IC50 = 332.0 nM 6.48
CHEMBL4756159 — IC50 = 342.0 nM 6.47
CHEMBL4753379 — IC50 = 347.0 nM 6.46
CHEMBL4784520 — IC50 = 360.0 nM 6.44
CHEMBL4751209 — IC50 = 377.0 nM 6.42
CHEMBL4759404 — IC50 = 402.0 nM 6.40
CHEMBL4779276 — IC50 = 452.0 nM 6.34
CHEMBL4764953 — IC50 = 454.0 nM 6.34
CHEMBL4758312 — IC50 = 469.0 nM 6.33
CHEMBL4783367 — IC50 = 471.0 nM 6.33
CHEMBL4294999 — IC50 = 471.0 nM 6.33
CHEMBL4756608 — IC50 = 488.0 nM 6.31
CHEMBL4745150 — IC50 = 496.0 nM 6.30
CHEMBL4752751 — IC50 = 528.0 nM 6.28
CHEMBL4747960 — IC50 = 528.0 nM 6.28
CHEMBL4751956 — IC50 = 533.0 nM 6.27
CHEMBL4799233 — IC50 = 552.0 nM 6.26
CHEMBL4752366 — IC50 = 556.0 nM 6.25
CHEMBL4786241 — IC50 = 573.0 nM 6.24
CHEMBL4777976 — IC50 = 593.0 nM 6.23
CHEMBL4792760 — IC50 = 590.0 nM 6.23
CHEMBL4786717 — IC50 = 619.0 nM 6.21
CHEMBL4783252 — IC50 = 619.0 nM 6.21
CHEMBL4763797 — IC50 = 641.0 nM 6.19
CHEMBL4762989 — IC50 = 662.0 nM 6.18
CHEMBL4753493 — IC50 = 665.0 nM 6.18
CHEMBL4740977 — IC50 = 671.0 nM 6.17
CHEMBL4752866 — IC50 = 746.0 nM 6.13
CHEMBL4761628 — IC50 = 756.0 nM 6.12
CHEMBL4764044 — IC50 = 810.0 nM 6.09
CHEMBL4778221 — IC50 = 803.0 nM 6.09
CHEMBL4754755 — IC50 = 837.0 nM 6.08
CHEMBL4787852 — IC50 = 848.0 nM 6.07
CHEMBL4784731 — IC50 = 845.0 nM 6.07
CHEMBL4762840 — IC50 = 845.0 nM 6.07
CHEMBL4792513 — IC50 = 882.0 nM 6.05