Assay Detail
Binding
CHEMBL4670710
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Inhibition of GS[HiBiT]GS-tagged LDHA (unknown origin) expressed in HEK-293T cells measured after 1 hr by CESTA
86
Total Activities
86
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 86 | 6.59 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4763797 | — | — | 1 | 7.42 |
| CHEMBL4784731 | — | — | 1 | 7.12 |
| CHEMBL4799233 | — | — | 1 | 7.10 |
| CHEMBL4762895 | — | — | 1 | 7.08 |
| CHEMBL4751495 | — | — | 1 | 7.08 |
| CHEMBL4784520 | — | — | 1 | 7.05 |
| CHEMBL4751209 | — | — | 1 | 7.05 |
| CHEMBL4791940 | — | — | 1 | 7.05 |
| CHEMBL4742726 | — | — | 1 | 7.05 |
| CHEMBL4788048 | — | — | 1 | 7.05 |
| CHEMBL4747300 | — | — | 1 | 7.05 |
| CHEMBL4784359 | — | — | 1 | 7.05 |
| CHEMBL4793796 | — | — | 1 | 7.02 |
| CHEMBL4780015 | — | — | 1 | 7.02 |
| CHEMBL4777976 | — | — | 1 | 7.02 |
| CHEMBL4777867 | — | — | 1 | 7.00 |
| CHEMBL4783367 | — | — | 1 | 7.00 |
| CHEMBL4762840 | — | — | 1 | 6.97 |
| CHEMBL4752866 | — | — | 1 | 6.97 |
| CHEMBL4748782 | — | — | 1 | 6.97 |
| CHEMBL4764953 | — | — | 1 | 6.97 |
| CHEMBL4753360 | — | — | 1 | 6.95 |
| CHEMBL4782843 | — | — | 1 | 6.95 |
| CHEMBL4752366 | — | — | 1 | 6.95 |
| CHEMBL4762989 | — | — | 1 | 6.95 |
| CHEMBL4778221 | — | — | 1 | 6.95 |
| CHEMBL4783945 | — | — | 1 | 6.92 |
| CHEMBL4779276 | — | — | 1 | 6.92 |
| CHEMBL4753379 | — | — | 1 | 6.92 |
| CHEMBL4787940 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4763797 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4784731 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL4799233 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4762895 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4751495 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4784359 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL4747300 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL4788048 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4742726 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL4791940 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL4751209 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL4784520 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4793796 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4780015 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4777976 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4777867 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4783367 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL4762840 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL4752866 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL4748782 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL4764953 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL4778221 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL4762989 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL4782843 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL4753360 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL4752366 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL4783945 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL4779276 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL4753379 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL4787940 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL4740977 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL4759378 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL4763489 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL4752751 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL4786241 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL4747960 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL4754755 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL4741188 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL4744588 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL4758227 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4749903 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4783252 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4758255 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL4294999 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL4758290 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL4754861 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL4763863 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4758312 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL4792760 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL4794789 | — | IC50 | = | 178.0 | nM | 6.75 |