Assay Detail
Binding
CHEMBL4670812
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to N-terminal His6-tagged human TEAD4 YAP binding domain (217 to 434 residues) expressed in Escherichia coli C43 (DE3) cells by ITC method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transcriptional enhancer factor TEF-3 (CHEMBL4295828) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Covalent Inhibitors Targeting the Transcriptional Enhanced Associate Domain Central Pocket.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 4.35 | 4.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63323 | NIFLUMIC ACID | 2.0 | 1 | 4.55 |
| CHEMBL23588 | FLUFENAMIC ACID | 2.0 | 1 | 4.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63323 | NIFLUMIC ACID | Kd | = | 28000.0 | nM | 4.55 |
| CHEMBL23588 | FLUFENAMIC ACID | Kd | = | 73000.0 | nM | 4.14 |