Assay Detail
Binding
CHEMBL4670872
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GPX4 in human LOX IMVI cells assessed as ferroptosis-mediated cell death measured as cell viability
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | LOX IMVI |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phospholipid hydroperoxide glutathione peroxidase GPX4 (CHEMBL4295754) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationships of GPX4 inhibitor warheads.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 48 | 5.86 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4747331 | — | — | 1 | 7.92 |
| CHEMBL1499544 | — | — | 1 | 7.55 |
| CHEMBL1951048 | — | — | 1 | 7.36 |
| CHEMBL4792343 | — | — | 1 | 6.82 |
| CHEMBL4760983 | — | — | 1 | 6.68 |
| CHEMBL1578061 | — | — | 1 | 6.47 |
| CHEMBL4780750 | — | — | 1 | 6.43 |
| CHEMBL4757878 | — | — | 1 | 6.38 |
| CHEMBL4748785 | — | — | 1 | 6.22 |
| CHEMBL4751224 | — | — | 1 | 6.00 |
| CHEMBL4800659 | — | — | 1 | 5.92 |
| CHEMBL4779501 | — | — | 1 | 5.92 |
| CHEMBL1469676 | — | — | 1 | 5.80 |
| CHEMBL4765119 | — | — | 1 | 5.75 |
| CHEMBL4761247 | — | — | 1 | 5.24 |
| CHEMBL4779048 | — | — | 1 | 5.00 |
| CHEMBL4758051 | — | — | 1 | 4.75 |
| CHEMBL4758630 | — | — | 1 | 4.66 |
| CHEMBL4794855 | — | — | 1 | 4.62 |
| CHEMBL4764852 | — | — | 1 | 4.51 |
| CHEMBL4783507 | — | — | 1 | 4.50 |
| CHEMBL4784730 | — | — | 1 | 4.32 |
| CHEMBL4755063 | — | — | 1 | - |
| CHEMBL4781953 | — | — | 1 | - |
| CHEMBL4741344 | — | — | 1 | - |
| CHEMBL4798158 | — | — | 1 | - |
| CHEMBL4788956 | — | — | 1 | - |
| CHEMBL4762626 | — | — | 1 | - |
| CHEMBL4758354 | — | — | 1 | - |
| CHEMBL4800033 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4747331 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1499544 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1951048 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4792343 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4760983 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1578061 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4780750 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4757878 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4748785 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4751224 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4800659 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4779501 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1469676 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4765119 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4761247 | — | EC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4779048 | — | EC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL4758051 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4758630 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4794855 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4764852 | — | EC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL4783507 | — | EC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL4784730 | — | EC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL4785219 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL4757990 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL4756558 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL4761568 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL4793839 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL4753327 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL4796262 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL4747623 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL4745951 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL4744602 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL4740507 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL4778553 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL4785072 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL4742976 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL4753730 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL4791648 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL4781918 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL4780613 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL4800033 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL4758354 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL4762626 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL4788956 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL4798158 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL4741344 | — | EC50 | = | 164000.0 | nM | - |
| CHEMBL4781953 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL4755063 | — | EC50 | > | 33000.0 | nM | - |