Assay Detail
Binding
CHEMBL4670997
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Binding affinity to Fc-tagged human PD-1 assessed as induction of dissociation of PD-1 N66A mutant/His-and Fc-tagged human PD-L1complex pre-incubated for 30 mins with PDL1 and measured after 1 hr by competitive ELISA
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Di-bromo-Based Small-Molecule Inhibitors of the PD-1/PD-L1 Immune Checkpoint.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.19 | 8.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4765124 | — | — | 1 | 8.83 |
| CHEMBL4071326 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4765124 | — | IC50 | = | 1.47 | nM | 8.83 |
| CHEMBL4071326 | — | IC50 | = | 28.04 | nM | 7.55 |