Assay Detail
ADMET
CHEMBL4671340
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTS assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, Structure-Activity Relationship, and Antimalarial Efficacy of 6-Chloro-2-arylvinylquinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 5.13 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4792510 | — | — | 1 | 5.50 |
| CHEMBL4742187 | — | — | 1 | 5.45 |
| CHEMBL4754527 | — | — | 1 | 5.32 |
| CHEMBL4793423 | — | — | 1 | 5.32 |
| CHEMBL4751906 | — | — | 1 | 5.27 |
| CHEMBL4741645 | — | — | 1 | 5.25 |
| CHEMBL4763354 | — | — | 1 | 5.21 |
| CHEMBL601778 | — | — | 1 | 5.15 |
| CHEMBL4791424 | — | — | 1 | 5.08 |
| CHEMBL4780437 | — | — | 1 | 4.99 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 4.98 |
| CHEMBL4757068 | — | — | 1 | 4.98 |
| CHEMBL4758877 | — | — | 1 | 4.95 |
| CHEMBL4749631 | — | — | 1 | 4.76 |
| CHEMBL4763704 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4792510 | — | EC50 | = | 3195.2 | nM | 5.50 |
| CHEMBL4742187 | — | EC50 | = | 3547.0 | nM | 5.45 |
| CHEMBL4754527 | — | EC50 | = | 4827.3 | nM | 5.32 |
| CHEMBL4793423 | — | EC50 | = | 4777.4 | nM | 5.32 |
| CHEMBL4751906 | — | EC50 | = | 5331.6 | nM | 5.27 |
| CHEMBL4741645 | — | EC50 | = | 5670.1 | nM | 5.25 |
| CHEMBL4763354 | — | EC50 | = | 6110.6 | nM | 5.21 |
| CHEMBL601778 | — | EC50 | = | 7019.1 | nM | 5.15 |
| CHEMBL4791424 | — | EC50 | = | 8377.7 | nM | 5.08 |
| CHEMBL4780437 | — | EC50 | = | 10178.2 | nM | 4.99 |
| CHEMBL76 | CHLOROQUINE | EC50 | = | 10430.0 | nM | 4.98 |
| CHEMBL4757068 | — | EC50 | = | 10430.0 | nM | 4.98 |
| CHEMBL4758877 | — | EC50 | = | 11235.3 | nM | 4.95 |
| CHEMBL4749631 | — | EC50 | = | 17204.6 | nM | 4.76 |
| CHEMBL4763704 | — | EC50 | = | 19760.6 | nM | 4.70 |