Assay Detail
Functional
CHEMBL4671365
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Antiplasmodial activity against synchronous gametocyte late stage of Plasmodium falciparum 3D7 harboring luc7 incubated for 72 hrs by ONE-Glo luciferase assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, Structure-Activity Relationship, and Antimalarial Efficacy of 6-Chloro-2-arylvinylquinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.42 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 7.43 |
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | 4.0 | 1 | 6.97 |
| CHEMBL4758877 | — | — | 1 | 6.41 |
| CHEMBL4751906 | — | — | 1 | 5.69 |
| CHEMBL4792510 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307261 | ARTENIMOL | EC50 | = | 37.4 | nM | 7.43 |
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | EC50 | = | 107.2 | nM | 6.97 |
| CHEMBL4758877 | — | EC50 | = | 393.6 | nM | 6.41 |
| CHEMBL4751906 | — | EC50 | = | 2049.3 | nM | 5.69 |
| CHEMBL4792510 | — | EC50 | = | 2495.7 | nM | 5.60 |